Imaging of Traumatic Intracranial Hemorrhage

pdf path

Image Gallery

Intracranial hemorrhage (ICH) is a common entity encountered in clinical emergency medicine. Imaging is the cornerstone in the diagnosis of traumatic ICH. In a large study of patients with a head injury and a decreased Glasgow Coma Scale (GCS), 46% of patients demonstrated intracranial hemorrhage. Of these, 30% were subdural hematomas (SDH), 22% were epidural hematomas (EDH), 22% were intraparenchymal hemorrhages (IPH), and 14% were subarachnoid hemorrhages (SAH).1 Current literature reports up to 72% incidence of diffuse axonal injury (DAI) in moderate to severe head injury.2 Timely and accurate diagnoses of ICH is key to successful patient management given the emergent nature of ICH.

CT is the initial modality of choice due to its accuracy, short study time, low cost, and robustness against artifacts. MR is also used given its increased sensitivity in detecting DAI, as well as subacute and chronic hemorrhage.3 Although lumbar punctures were previously more common in the diagnostic workup of SAH, there has been a paradigm shift away from performing this procedure, as nonenhanced CT (NECT) has been shown to be highly accurate in detecting SAH when performed within 6 hours of symptom onset.4

This article will review the key vascular anatomy associated with ICH followed by a strategy for imaging evaluation and reporting. This is followed by a detailed review of the different types of traumatic ICH with an emphasis on imaging findings.

Meningeal Vascular Anatomy

The three meningeal layers (dura, arachnoid and pia mater) are perfused by the anterior, middle and posterior meningeal arteries. The anterior and posterior meningeal arteries originate from the anterior ethmoidal and ascending pharyngeal arteries, respectively, and perfuse dura of the anterior and posterior cranial fossa.5 The middle meningeal artery, a maxillary artery branch, enters the skull at the foramen spinosum.5 Trauma to the parietotemporal skull can lacerate these vessels resulting in hemorrhage.6

The meningeal venous drainage occurs via dural sinuses, located between the periosteum of the skull and the dura mater, mainly via the superior sagittal, transverse and sigmoid sinuses. Central brain regions drain via the inferior sagittal sinus and great vein of Galen into the straight sinus. Relatively small venous blood volumes exit the skull through the cavernous sinus and ophthalmic veins.7 Injury to bridging veins leads to SDH; injury to the cerebral veins/arteries leads to SAH. Skull-base fractures can injure a dural sinus, which bears the probability of massive blood loss into an extra-axial hematoma.

Imaging Evaluation and Reporting

Given the critical nature of ICH, the interpreting physician must take necessary steps to prevent overlooking ICH on imaging. Although axial imaging is the standard for evaluating head CT, using additional reconstructions should be considered in routine clinical practice. ICH detection rate increases when axial and coronal images are viewed.9 Among missed acute intracranial hemorrhages, SDH accounts for 39%, followed by SAH with 33%.10 A customized checklist approach (Table 1) may be beneficial to the radiologist, particularly to ensure classic areas for subtle findings are evaluated (Figure 1). CT windows should also be considered when interpreting studies as subtle findings may be obscured due to windowing. In addition to standard CT head windows, the authors’ institution has found a width of 99 Hounsfield units, level of 93 HU images can make hemorrhage optically more conspicuous (Figure 2).

Additionally, it is important to have a general understanding of imaging findings and information that referring physicians need to guide management. In particular, findings that help determine a need for surgical decompression/evacuation should be reported, although the decision for surgery is based on clinical information in addition to imaging. When encountering ICH on CT or MR several items should be routinely reported including midline shift (particularly if > 5 mm), hematoma thickness/volume, mass effect, effacement of ventricles and/or cisterns, evidence of herniation, evidence of hydrocephalus, and coexistent injuries such as skull fractures and intracranial foreign bodies.11

Imaging Features of Intracranial Hemorrhage

Diffuse Axonal Injury

Unequal rotational and acceleration-deceleration forces cause the brain to pivot around the brainstem, causing stretching and shearing of axons and resulting in the clinical diagnosis of DAI. Shear forces peak at the grey-white matter interface, due to its peripheral location and differences in tissue density; hence, 67% of DAI lesions are in this region.12 In more severe cases, additional sites of injury occur in the brainstem. Within hours, axonal deformation damages its cytoskeleton, resulting in arrest of axoplasmic flow on a microscopic level, followed by axonal swelling and subsequently axon rupture.13 Mechanisms of injury vary, but include high-impact falls and motor vehicle accidents.

Foci of axonal edema with or without hemorrhage are imaging findings of DAI and these foci may vary in size (Figure 3). Despite DAI being present in up to 72% of patients with moderate to severe head injuries, 50% to 80% of initial CT and MRI studies are negative.2 MRI is more sensitive than CT in detecting lesions (Figure 4).12-14 Gradient echo (GRE) and susceptibility-weighted imaging (SWI) are the most sensitive sequence, revealing the highest number of lesions at the highest number of locations compared to other MR sequences. The classic triad seen in DAI is diffuse damage to axons, a focal lesion in the corpus callosum, and a focal lesion in the dorsolateral quadrant of the rostral brainstem adjacent to the superior cerebellar peduncles.12 DAI lesions detected within 4 weeks after injury improve functional status and long-term outcome due to changes in patient management.15 Therefore, MRI is recommended within 4 weeks of traumatic brain injury (TBI).16

Intraparenchymal Hemorrhage

Traumatic acute IPH, commonly referred to as a cerebral contusion, usually occurs after a significant direct head injury. It commonly involves brain parenchyma adjacent to bony protuberance/dural fold.5 CT displays a patchy, irregular, hyperdense area of acute hemorrhage on an edematous background (Figure 5). Hemorrhages may be multiple and bilateral. Cerebral edema may be relatively mild acutely; however, progression of cerebral edema is common and can result in midline shift and herniation syndromes. IPH can be complicated by continued enlargement and/or re-hemorrhage. Likewise, new lesions can be detected on follow-up imaging. MRI is useful to identify traumatic intraparenchymal damage without blood products, termed nonhemorrhagic cerebral contusion (Figure 6). Sequelae after resolution are common and include gliosis, encephalomalacia and associated volume loss.

Subdural Hematoma

Acute SDH is characterized by an extra-axial crescent-shaped hemorrhage in a potential space between the dura and arachnoid. A direct blow to the head is not necessary to incur an SDH. Instead, an SDH may be related to acceleration-deceleration forces secondary to the impact from a fall or shaking of an infant.17 Regardless of the mechanism, shear forces on the bridging veins or cortical arteries can lead to injury and rupture.18-20 Elderly are predisposed to develop SDH due to cortical atrophy. Additionally, anticoagulants and antiplatelet agents (Figure 7) raise concern for increased risk of hemorrhage. Contrary to epidural hematomas, classic SDH are limited by dural duplications, but can cross suture lines and, therefore, can extend over an entire hemisphere. The vast majority of small, atypically shaped, extra-axial hemorrhages are due to a low-pressure venous injury causing an SDH with continued CT follow-up suggested if clinical doubt remains as to whether an extra-axial blood collection reflects an EDH or SDH.

It is valuable for the radiologist to be generally aware of the appearance of blood products on CT based on the acuity. Although imaging may not occur this early, in the first few hours (hyperacute phase), SDH might be isodense to the underlying cortex, as it is still liquid (40-50 HU), and may not be detectable. Hemorrhage becomes increasingly dense as it coagulates and condenses during the acute phase (0-3 days) due to clot retraction by a decreased fluid component and relative increase in iron content in the red blood cells. Those clots measure between 80-100 HU and show the typical hyperattenuation. The attenuation decreases in the subacute phase as the blood products degrade and eventually becomes similar to CSF density in the chronic phase (Figure 8).21

SDH requires heightened vigilance and follow-up imaging to ensure early detection of complications, such as continued bleeding, rebleeding (8% of cases), midline shift, or herniation.22 Mixed attenuation blood in which isodense areas are intermixed by hyperdense areas suggest active (re)bleeding, which is termed the “swirl sign” on NECT. Cerebral spinal fluid in the subdural space (subdural hygromas) is thought to be related to subdural hematomas. An arachnoid membrane tear with a “flap-valve” mechanism results in CSF leakage into the subdural space.23,24

Epidural Hematoma

Hemorrhage into a potential space between the inner table of the skull and the dura mater occurs in 1% of minor head injury and 10% following head injury in patients who present in a comatose state.25,26 A provided history of head injury days-to-months prior to imaging should not eradicate the possibility of an EDH, as 20% to 50% of patients experience a symptom-free lucid interval.27 Of patients with an EDH, 91% suffer from an associated skull fracture.28 Typically supratentorially located, EDH frequently involves injury to the middle meningeal artery or anterior ethmoidal artery. Rapid hematoma expansion is common due to the relatively high pressure of arterial blood.29 Classic CT findings are a high-density convex or biconvex shaped extra-axial fluid collection that does not cross the sutures (Figure 9).

Venous epidural hemorrhage accounts for 5% to 10% of all EDH and occurs at specific locations including the vertex (superior sagittal sinus injury), anterior middle cranial fossa (sphenoparietal sinus injury), and posterior occipital region (transverse/sigmoid sinus injury). The latter can rapidly cause tonsillar herniation. However, the majority of venous EDH are unlikely to expand because venous pressure is insufficient to further strip off the dura from the skull.30 Similar to arterial EDH, an associated fracture/diastasis is common. Venous EDH typically displaces the sinus away from the fracture and, in contrast to arterial EDH, can occasionally cross suture lines (Figure 10). One should suspect a venous EDH if a skull fracture runs through the expected location of a dural sinus.

Rarely, direct bleeding from a skull fracture causes EDH.5 Similar to the other causes of ICH, co-existent and/or complicating findings may be encountered including mass effect, rebleeding, herniation, brain edema, and/or intraparenchymal hemorrhage.31-32 Similar to SDH, the appearance of the blood on CT and MR depends on its age, as hemoglobin is progressively degraded over time.33

Traumatic Subarachnoid Hemorrhage

Traumatic SAH (tSAH) results from disruption of pial vessels with bleeding into the subarachnoid space. It is often coexistent with other pathologies in the setting of trauma. Vessel injury more commonly arises in the cerebral convexities/sulci following a high-impact mechanical force to the head. Of patients with severe TBI, 40% develop tSAH.34 Be cautious with SAH in the setting of acute trauma as differential diagnosis includes tSAH as well as nontraumatic SAH (eg, ruptured aneurysm) that may have preceded (and perhaps led to) the reported trauma (Figure 11). Differentiating traumatic from nontraumatic SAH by imaging is not always possible. However, SAH identified around the cerebral convexities with relative sparing of the basilar cisterns around the circle of Willis would favor trauma.35 Similarly, SAH associated with other signs of trauma on CT such as a countercoup pattern associated with a parenchymal contusion may also favor a traumatic etiology. When doubt exists, the CT or traditional angiography may be performed for further evaluation to exclude an aneurysm.

Imaging characteristics that portend a worse prognosis include other evidence of brain trauma including brain contusions, especially if enlarging.36 Complications of tSAH include hydrocephalus and cerebral vasospasm.35,37 Table 2 summarizes differentiating key features of EDH, SDH and SAH.

Conclusion

Traumatic intracranial hemorrhage is an urgent finding requiring prompt and accurate evaluation by the interpreting radiologist with excellent communication and documentation of key findings that may affect patient management. Given the trauma and further complicating patient management, additional critical coexistent injuries may also be present and require urgent treatment. Thus, at many medical centers a multidisciplinary neurotrauma team guides management and determines the need for surgical decompression/evacuation (Figure 12).

Furthermore, the radiologist must be vigilant about new and/or worsening edema, midline shift, signs of hydrocephalus, worsening hemorrhage (rebleeding), or other complicating factors on follow-up studies that may alter patient management. Medical and surgical management in these patients is complex and multifactorial requiring timely and accurate imaging information, thus solidifying the radiologists’ key role in the management of traumatic ICH.

References

  1. Perel P, Roberts I, Bouamra O, Woodford M, Mooney J, Lecky F. Intracranial bleeding in patients with traumatic brain injury: a prognostic study. BMC Emerg Med 2009;9:15.
  2. Skandsen T, Kvistad KA, Solheim O, Strand IH, Folvik M, Vik A. Prevalence and impact of diffuse axonal injury in patients with moderate and severe head injury: a cohort study of early magnetic resonance imaging findings and 1-year outcome. J Neurosurg 2010;113(3):556-563.
  3. Kidwell CS, Chalela JA, Saver JL, et al. Comparison of MRI and CT for detection of acute intracerebral hemorrhage. JAMA 2004;292(15):1823-1830.
  4. Carpenter CR, Hussain AM, Ward MJ, et al. Spontaneous subarachnoid hemorrhage: a systematic review and meta-analysis describing the diagnostic accuracy of history, physical examination, imaging, and lumbar puncture with an exploration of test thresholds. Acad Emerg Med 2016;23(9):963-1003.
  5. Yousem, D, Zimmerman R, Grossman R. In Nadgir R, ed. Neuroradiology: The Requisites. 3rd Edition. Philadelphia, PA: Mosby/Elsevier. 2010. https://www.elsevier.com/books/neuroradiology-the-requisites/yousem/978-0-323-04521-6. Accessed April 14, 2019.
  6. Aurangzeb A, Ahmed E, Afridi EA, et al. Frequency of extradural haematoma in patients with linear skull fracture. J Ayub Med Coll Abbottabad 2015;27(2):314-317.
  7. Mancall EL, Brock, DG. Gray’s Clinical Neuroanatomy. Philadelphia, PA: Elsevier/Saunders; 2011. https://www.us.elsevierhealth.com/grays-clinical-neuroanatomy-9781416047056.html. Accessed April 14, 2019.
  8. Cranial Vault & Skull Base - Diagnosis - Skull base, Anterior skull base fractures - AO Surgery Reference. https://www2.aofoundation.org/wps/portal/!ut/p/a0/04_Sj9CPykssy0xPLMnMz0vMAfGjzOKN_A0M3D2DDbz9_UMMDRyDXQ3dw9wMDAzMjfULsh0VAbWjLW0!/?bone=CMF&classification=93-Skull%20base%2C%20Anterior%20skull%20base%20fractures&segment=Cranium&showPage=diagnosis&teaserTitle=&contentUrl=srg/93/01-Diagnosis/skull_base-skull_base.jsp. Accessed April 14, 2019.
  9. Wei SC, Ulmer S, Lev MH, Pomerantz SR, González RG, Henson JW. Value of coronal reformations in the CT evaluation of acute head trauma. Am J Neuroradiol 2010;31(2):334-339.
  10. Strub WM, Leach JL, Tomsick T, Vagal A. Overnight preliminary head CT interpretations provided by residents: locations of misidentified intracranial hemorrhage. Am J Neuroradiol 2007;28(9)1679-1682. http://www.ajnr.org/content/28/9/1679. Accessed April 14, 2019.
  11. Escobedo LVS, Habboushe J, Kaafarani H, Velmahos G, Shah K, Lee J. Traumatic brain injury: a case-based review. World J Emerg Med 2013;4(4):252-259.
  12. Parizel PM, Ozsarlak, Van Goethem JW, et al. Imaging findings in diffuse axonal injury after closed head trauma. Eur Radiol. 1998;8(6):960-965.
  13. Hill CS, Coleman MP, Menon DK. Traumatic axonal injury: mechanisms and translational opportunities. Trends Neurosci 2016;39(5):311-324.
  14. Kinoshita T, Moritani T, Hiwatashi A, et al. Conspicuity of diffuse axonal injury lesions on diffusion-weighted MR imaging. Eur J Radiol 2005;56(1):5-11.
  15. Bansal M, Sinha VD, Bansal J. Diagnostic and prognostic capability of newer magnetic resonance imaging brain sequences in diffuse axonal injury patient. Asian J Neurosurg 2018;13(2):348-356.
  16. Moen KG, Brezova V, Skandsen T, Håberg AK, Folvik M, Vik A. Traumatic axonal injury: the prognostic value of lesion load in corpus callosum, brain stem, and thalamus in different magnetic resonance imaging sequences. J Neurotrauma 2014;31(17):1486-1496.
  17. Gennarelli TA, Thibault LE. Biomechanics of acute subdural hematoma. J Trauma 1982;22(8):680-686.
  18. DeKosky ST, Ikonomovic MD, Gandy S. Traumatic brain injury--football, warfare, and long-term effects. N Engl J Med 2010;363(14):1293-1296.
  19. Maxeiner H, Wolff M. Pure subdural hematomas: a postmortem analysis of their form and bleeding points. Neurosurgery 2007;61(1 Suppl):267-272; discussion 272-273.
  20. Haines DE, Harkey HL, al-Mefty O. The “subdural” space: a new look at an outdated concept. Neurosurgery 1993;32(1):111-120.
  21. Berlin L. Avoiding errors in radiology: case-based analysis of causes and preventive strategies. JAMA 2011;306(11):1267-1268.
  22. Lee K-S, Shim J-J, Yoon S-M, Doh J-W, Yun I-G, Bae H-G. Acute-on-Chronic subdural hematoma: not uncommon events. J Korean Neurosurg Soc 2011;50(6):512-516.
  23. Duy L, Badeeb A, Duy W, et al. CT Attenuation of acute subdural hematomas in patients with anemia. J Neuroimaging 2019, February 16.
  24. McCluney KW, Yeakley JW, Fenstermacher MJ, Baird SH, Bonmati CM. Subdural hygroma versus atrophy on MR brain scans: “the cortical vein sign.” AJNR Am J Neuroradiol 1992;13(5):1335-1339.
  25. Baykaner K, Alp H, Ceviker N, Keskil S, Seçkin Z. Observation of 95 patients with extradural hematoma and review of the literature. Surg Neurol 1988;30(5):339-341.
  26. Freytag E. Autopsy findings in head injuries from blunt forces. Statistical evaluation of 1,367 cases. Arch Pathol 1963;75:402-413.
  27. Kushner D. Mild traumatic brain injury: toward understanding manifestations and treatment. Arch Intern Med 1998;158(15):1617-1624.
  28. Zimmerman RA, Bilaniuk LT. Computed tomographic staging of traumatic epidural bleeding. Radiology 1982;144(4):809-812.
  29. de Andrade AF, Figueiredo EG, Caldas JG, et al. Intracranial vascular lesions associated with small epidural hematomas. Neurosurgery 2008;62(2):416-420; discussion 420-421.
  30. Gean AD, Fischbein NJ, Purcell DD, Aiken AH, Manley GT, Stiver SI. Benign anterior temporal epidural hematoma: indolent lesion with a characteristic CT imaging appearance after blunt head trauma. Radiology 2010;257(1):212-218.
  31. Bullock MR, Chesnut R, Ghajar J, et al. Surgical management of acute epidural hematomas. Neurosurgery 2006;58(3 Suppl):S7-15; discussion Si-iv.
  32. Glastonbury CM, Gean AD. Current neuroimaging of head injury. Semin Neurosurg 2003;14:79-88.
  33. Hosoda K, Tamaki N, Masumura M, Matsumoto S, Maeda F. Magnetic resonance images of chronic subdural hematomas. J Neurosurg 1987;67(5):677-683.
  34. Jaeger M, Meixensberger J. Traumatic subarachnoid hemorrhage and its clinical relevance. Intensivmed Notfallmedizin 2004;41(3):148-152.
  35. Heit JJ, Iv M, Wintermark M. Imaging of intracranial hemorrhage. J Stroke 2017 Jan;19(1):11-27.
  36. Chieregato A, Fainardi E, Morselli-Labate AM, Antonelli V, et al. Factors associated with neurological outcome and lesion progression in traumatic subarachnoid hemorrhage patients. Neurosurgery 2005;56(4):671-680.
  37. Biedert S, Wolfshörndl H. Extraventricular obstructive hydrocephalus. Fortschr Neurol Psychiatr. 1994;62(11):405-408.
  38. Verma RK, Kottke R, Andereggen L, et al. Detecting subarachnoid hemorrhage: comparison of combined FLAIR/SWI versus CT. Eur J Radiol 2013;82(9):1539-1545.
  39. Winn W. Youmans and Winn Neurological Surgery, 4-Volume Set. 7th ed. Philadelphia, PA: Elsevier; 2016. https://www.elsevier.com/books/youmans-and-winn-neurological-surgery-4-volume-set/winn/978-0-323-28782-1. Accessed April 14, 2019.
Back To Top

Koegel C, McCallum R, Greenhill M, López García D, Kohli A, Mallon M, Koenigsberg RA, Kazmi KS.  Imaging of Traumatic Intracranial Hemorrhage.  J Am Osteopath Coll Radiol.  2019;8(3):13-20.

About the Author

Christian Koegel, M.D., Raluca McCallum, M.D., Mark Greenhill, B.S., Diana López García, M.D., Ajay Kohli, M.D., Mea Mallon, M.D

Christian Koegel, M.D., Raluca McCallum, M.D., Mark Greenhill, B.S., Diana López García, M.D., Ajay Kohli, M.D., Mea Mallon, M.D

Dr. Koegel, Dr. McCallum, Mr. Greenhill, Dr. López García, Dr. Kohli, and Dr. Mallon work with the Departments of Radiology, Hahnemann University Hospital and St. Christopher Children’s Hospital; Dr. Koenigsberg and Dr. Kazmi, are with Drexel University, Philadelphia, PA.


 

Copyright © The American College of Osteopathic Radiology 2019
    Agility CMS