Update on Emergency Imaging of Acute Ischemic Stroke

pdf path

Image Gallery

Introduction

The term acute stroke refers to a constellation of symptoms and clinical signs that indicate the presence of a sudden neurological injury secondary to vascular occlusion or injury. As many as 20 million people are afflicted by stroke annually worldwide, and the prevalence of stroke survivors is at least 60 million by some estimates.1 Stroke is a significant cause of mortality, resulting in more than 140,000 deaths annually in the US alone, and stroke survivors suffer long-term neurological impairment, decreased quality of life, and represent a significant burden to society in both expense of management and loss of productivity.2

The underlying causes of acute stroke are commonly grouped into three categories: ischemic, hemorrhagic, and venous. Ischemic stroke, arising from acute arterial occlusion and subsequent ischemic injury and infarct, accounts for approximately 80% of acute strokes and will be the primary focus of this review. The other 20% of acute strokes are classified as hemorrhagic stroke, which includes primary intracranial parenchymal and subarachnoid hemorrhages, and venous stroke, which is caused by occlusion of the intracranial venous sinuses and cortical veins and results in distinctive patterns of congestive injury and hemorrhage.3

Emergency imaging plays a key role in the management of acute stroke.4,5 The initial goal of imaging in acute stroke is to exclude the presence of intracranial hemorrhage prior to the initiation of intravenous tissue plasminogen activator (IV tPA) in eligible patients. After hemorrhage is excluded, the secondary goals are to identify the location of the arterial occlusion and to characterize the affected brain parenchyma as irreversibly damaged (infarct) or “at risk” for infarction (ischemic penumbra) when endovascular therapy is available. Finally, global assessment of the arteries of the head and neck is recommended in all patients following acute stroke5 to help identify the mechanism of the stroke and stratify future risk, and to identify the location of occlusion for possible endovascular revascularization, where available.

Commonly used imaging modalities for stroke include computed tomography (CT) and magnetic resonance (MR) techniques, including nonenhanced CT (NECT); abbreviated MR protocols using T2 fluid attenuated inversion recovery (FLAIR)-weighted sequences, T2*-weighted gradient-echo (GRE) and susceptibility-weighted (SWI) sequences, and diffusion weighted (DWI, DTI) and apparent diffusion coefficient (ADC) MR; CT angiography (CTA) and MR angiography (MRA); and CT or MR perfusion (pCT and pMR, respectively). Doppler ultrasound (DUS) is appropriate for evaluation of the vessels of the neck, although review of carotid ultrasound is beyond the scope of this article.

Nonenhanced Computed Tomography

Computed tomography is the initial imaging evaluation of choice in patients with clinically suspected acute stroke due to its wide availability, short exam duration, and high presumed negative predictive value for acute intracranial hemorrhage (ICH). The presence of acute intracranial hemorrhage is an absolute contraindication for administration of IV tPA and must be performed and interpreted rapidly in order to prevent delays in therapy for eligible patients. In addition, other possible etiologies of the patient’s neurological deficits (e.g. intracranial mass, hydrocephalus, etc.) may be suggested at the time of the initial NECT exam.

Initial scans are often grossly normal or nonspecific following acute ischemic stroke prior to the onset of parenchymal edema and swelling. The hyperdense (or dense) MCA sign (Fig. 1) and related dot sign (Fig. 2) are insensitive but specific early findings in M1 or M2 segment MCA ischemic strokes, representing high attenuation thrombus within the affected vessel. These signs are of particular importance, because they may be present from the very onset of the vascular insult prior to any additional NECT findings. Hyperdense thrombus may also be seen in less commonly involved vessels, including the intracranial ICAs, anterior cerebral arteries (ACAs), posterior cerebral arteries (PCAs), and basilar artery.

A later, but early sign of proximal M1 or proximal M2 occlusion is the insular ribbon sign (Fig. 3), representing loss of normal grey-white matter attenuation differentiation in the insula due to cytotoxic edema. Developing cytotoxic edema may also result in an indistinct or hypoattenuated appearance of the architecture of the basal ganglia relative to the contralateral side referred to as a “disappearing” basal ganglia sign (Fig. 4).

As the ischemia progresses to infarction and cytotoxic edema continues to develop, occlusions involving larger vascular territories will be evident as geographic regions of decreased attenuation in a vascular distribution with associated loss of normal grey-white matter differentiation (Fig. 5). Accurate description of the size of the region has prognostic significance. The Alberta Stroke Program Early CT Score (ASPECTS) criteria divides the subcortical and cortical brain into 10 standardized zones; MCA strokes scoring 7 or more affected zones are associated with higher risk for symptomatic hemorrhage and a poor functional outcome. Similarly, the “one-third” rule stipulates that if greater than 1/3 of the MCA territory is affected, there is a greater risk of symptomatic stroke.6,7

MRI

Some institutions use protocols in which MRI is used in initial evaluation of suspected acute stroke. Acute stroke MRI protocols are typically abbreviated relative to protocols for non-acute stroke and other disease entities, and are often limited to DWI/ADC, T2*, and T2 FLAIR sequences. There are several disadvantages of MRI relative to NECT. Even stroke-specific MRI scan times are longer than NECT exams and protocols must not overly delay (or prevent) tPA administration for eligible patients. MRI is more likely to be degraded by patient motion and may be nondiagnostic in patients who are unable to fully cooperate. Patients with metallic hardware in the head and/or neck and patients with implanted electronic devices (e.g. pumps, pacemakers, nerve simulators) are similarly poor candidates for MR based imaging. Benefits of MR protocols include decreased exposure to ionizing radiation, improved detection of posterior fossa stroke, better characterization of stroke mimics, and superior differentiation between acute and chronic ischemic changes.3

In the initial evaluation for evidence of intracranial hemorrhage, T2* sensitive sequences (i.e. GRE and SWI) are highly sensitive8, appearing as low signal “blooming” caused by local magnetic field inhomogeneity (Fig. 6). Despite high sensitivity for the presence of blood, residual hemosiderin from prior hemorrhage and benign intracranial calcifications are confounding (Fig. 7) and may be indistinguishable from acute blood products if comparison imaging is not available. Punctate regions of suspected “microhemorrhages” may be present and should be reported; these commonly represent sequelae of prior hypertensive or amyloid angiopathy and hemorrhage, and it has been suggested that a large number of these lesions may increase the risk of hemorrhage following thrombolysis.9,10,11

There is a high degree of concordance between MR and NECT findings in acute cerebral ischemic stroke, although MRI is more sensitive than NECT for detecting anterior circulation stroke in the first 24 hours after vessel occlusion.12 T2 FLAIR is more sensitive for early cerebral edema than conventional T2 sequences, demonstrating coarsening of the cortical sulci, increased parenchymal volume, and abnormal signal hyperintensity (Fig. 8A and B), and will be almost universally abnormal 6-7 hours following stroke onset, compared to 12-24 hours for T2.

DWI is superior to NECT in the detection of acute ischemia in the brain, with a sensitivity reported up to 99% by 24 hours.13,14 Ischemia results in rapid cytotoxic edema and decreased membrane permeability, leading to a decrease in ADC values and corresponding increase in DWI signal characteristic of restricted diffusion (Fig. 8C and D) which correspond with late acute appearance of NECT (Fig. 8E). DWI will detect smaller infarctions than NECT and is the preferred modality for evaluation of patients presenting with TIA15, potentially demonstrating small infarcts that would otherwise remain undiagnosed. The presence of restricted diffusion in patients presenting with TIA is associated with higher incidence of future ischemic events,16,17,18 and the distribution of findings may be used to identify the etiology of the ischemic injury. Specifically, lesions in multiple vascular distributions suggest thromboembolic disease; bilateral strokes are associated with cardioembolic disease; and “watershed” infarcts suggest proximal high-grade vascular stenosis (Fig. 9).

In posterior fossa ischemia, the large volume and proximity of high density compact bone in the skull base causes local beam hardening, which severely limits detection of subtle brain attenuation changes in the posterior fossa and brainstem with NECT. DWI is largely unaffected, and even small regions of restricted diffusion may be readily evident (Fig. 10).

MR and CT Angiography

Early angiography of the head and neck is increasingly a component of acute stroke imaging. CT angiography is more widely used; eligible patients may be administered IV tPA while still in the scanner following initial NECT imaging to exclude hemorrhage and immediately be rescanned with contrast for angiography of the head and neck with or without pCT, depending on the institutional protocol.

Although both CTA and MRA have similar accuracy in identifying proximal anterior circulation occlusions,19 each modality has its limitations. Although more widely used, CT angiography is contraindicated in patients with a history of severe contrast reaction and is relatively contraindicated in patients with severe renal insufficiency, although contrast induced nephropathy (CIN) may be an acceptable risk in stroke patients. CT-based imaging is degraded by metallic artifact and posterior fossa beam hardening. MRI/MRA may expedited in patients with suspected posterior fossa stroke, as discussed above; however, MRA presents its own limitations. In addition to general MR considerations discussed above, risk of nephrogenic systemic fibrosis (NSF) limits the use of gadolinium- based contrast for contrast-enhanced MRA, although noncontrast time-of-flight techniques may still be applied. Time-of-flight noncontrast MRA, however, is subject to flow-related loss of signal which may simulate or overestimate stenosis in affected vessels.

In patients with intracranial hemorrhage, CTA of the head is routinely performed to evaluate for a causative lesion (e.g. aneurysm, tumor, vascular malformation, etc.). In institutions where endovascular therapy is available, head and neck CTA allows for identification of the site of occlusion to guide possible endovascular therapy in patients ineligible for IV tPA (e.g outside the 0-4.5 hour treatment window) or with large ICA and MCA occlusions20,21, as discussed below.

MR and CT Perfusion Imaging

Both pCT and pMR are techniques available to further characterize a suspected region of ischemia. Both techniques attempt to delineate irreversibly damaged or infarcted parenchyma from potentially retrievable “at risk” non-infarcted brain tissue. The leading motivation for this distinction is two-fold: large regions of “at risk” brain outside the IV tPA window and proximal occlusions that are less likely to respond to IV tPA alone may be indications for endovascular therapy.

It is important to note the current state of the literature regarding the use of both endovascular revascularization therapy and the use of perfusion imaging in evaluating stroke. Some evidence exists for therapeutic benefit of intra-arterial tPA administered up to 6 hours post onset22,23 or mechanical thrombectomy even after the 0-4.5 hour IV tPA window has passed.24,25 Subsequent trials, however, have challenged the efficacy of these therapies,26-28 and additional trials are necessary to more accurately identify patients who may benefit from intrarterial thrombolysis and mechanical thrombectomy. In addition, although perfusion imaging is often performed prior to endovascular therapy as a component of patient selection, to date several trials have not demonstrated strong prognostic value of perfusion imaging in predicting IV or endovascular therapy outcomes.29-32 Institution-specific and clinical trial guidelines, however, are used to determine reperfusion eligibility based on the size of the infarct core, largely based on the known increased risk of hemorrhage in patients based on established NECT criteria.

Perfusion imaging is proposed as a potentially useful assessment of remaining viable ischemic tissue that may benefit from reperfusion, and the basis of perfusion imaging is the different imaging characteristics of ischemic and infarcted brain. Prolonged ischemia may progress to infarct, although the time from ischemia to infarction varies by patient. Quantitatively, cerebral ischemia is associated with CBF of less than 20-25 ml/100g/min,33,34 and values of 12-25 ml/100g/min are more likely to recover with return of normal perfusion.

In pCT, quantification of inflow of contrast material allows calculation of blood flow (cerebral blood flow, CBF, and mean transit time, MTT) and blood volume (cerebral blood volume, CBV). Brain parenchyma with decreased CBF, increased MTT, and normal CBV suggests ischemia without infarct, or a vascular penumbra of brain “at risk” of infarct. Decreased CBV is associated with greater degree of cerebral edema and cell death. The “mismatch” between decreased CBF and decreased CBV is believed to represent brain that may recover if perfusion is normalized (Figs. 11 and 12A-C).

Although less widely used, in pMR, the penumbra is determined by the mismatch between the region of decreased CBF (calculated during dynamic imaging during administration of gadolinium-based contrast) and the size of the core infarct determined by DWI. This is analogous in interpretation to CT-based perfusion techniques.

Summary

Imaging of acute stroke is routine practice in emergency radiology. Although institutional variation exists, established evidence-driven guidelines direct the standard of care in order to enable timely and effective medical management. Both CT and MR based techniques are effective in the diagnosis and characterization of both ischemic and hemorrhagic stroke and vascular imaging of the head and neck is routinely performed at the time of initial presentation for prognostic purposes and to guide possible endovascular therapy, where available. Vascular and perfusion imaging may be incorporated into protocols to assess patient eligibility for endovascular therapy; however, additional study is needed to better establish value of both perfusion imaging and endovascular therapy.

References

  1. Mukherjee D and Patil CG. Epidemiology and the global burden of stroke. World Neurosurg 2011; 76(6 Suppl): S85-90.
  2. Centers for Disease Control and Prevention. Stroke Facts. Retrieved from: http://www.cdc.gov/stroke/facts.htm . June 1, 2014.
  3. Osborn AG. Arterial anatomy and strokes. In: Osborn AG. Osborn’s Brain, 1st ed. Amirsys, Inc; 2013: 169-214.
  4. DeLaPaz RL, Wippold FJ 2nd, Cornelius RS, et al. ACR appropriateness criteria® on cerebrovascular disease. J Am Coll Radiol 2011;8:532-38.
  5. Wintermark M, Sanelli P, Albers GW, et al. Imaging recommendations for acute stroke and transient ischemic attack patients: a joint statement by the American Society of Neuroradiology, the American College of Radiology, and the Society of NeuroInterventional Surgery. Am J Neuroradiol 2013; 34:E117-E27.
  6. Barber PA, Demchuk AM, Zhang J, et al. Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy; ASPECTS study group – Alberta Stroke Programme Early CT Score. Lancet 2000;355:1670-74.
  7. Wahlgren N, Ahmed N, Eriksson N, et al. Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke Monitoring Study (SITS-MOST). Stroke 2008; 39:3316- 22.
  8. Fiebach JB, Schellinger PD, Gass A, et al. Stroke magnetic resonance imaging is accurate in hyperacute intracerebral hemorrhage: a multicenter study on the validity of stroke imaging. Stroke 2004;35:502-06.
  9. Boulanger JM, Coutts SB, Eliasziw M, et al. Cerebral microhemorrhages predict new disabling or fatal strokes in patients with acute ischemic stroke or transient ischemic attack. Stroke 2006;37:911–14.
  10. Fiehler J, Albers GW, Boulanger JM, et al. Bleeding Risk Analysis in Stroke Imaging before Thrombolysis (BRASIL): pooled analysis of T2*-weighted magnetic resonance imaging data from 570 patients. Stroke 2007;38:2738––44.
  11. Lee SH, Kang BS, Kim N, et al. Does microbleed predict haemorrhagic transformation after acute artherothrombotic or cardioembolic stroke? J Neurol Neurosurg Psychiatry 2008;79:913-16.
  12. Brazzelli M, Sandercock PA, Chappell FM, et al. Magnetic resonance imaging versus computed tomography for detection of acute vascular lesions in patients presenting with stroke symptoms. Cochrane Database Syst Rev 2009:CD007424.
  13. Fiebach JB, Schellinger PD, Jansen O, et al. CT and diffusion-weighted MR imaging in randomized order: diffusion- weighted imaging results in higher accuracy and lower interrater variability in the diagnosis of hyperacute ischemic stroke. Stroke 2002;33:2206–10.
  14. Chalela JA, Kidwell CS, Nentwich LM, et al. Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison. Lancet 2007;369:293–98.
  15. Kidwell CS, Alger JR, Di Salle F, et al. Diffusion MRI in patients with transient ischemic attacks. Stroke 1999;30:1174–80.
  16. Coutts SB, Hill MD, Simon JE, et al. Silent ischemia in minor stroke and TIA patients identified on MR imaging. Neurology 2005;65:513–17.
  17. Easton JD, Saver JL, Albers GW, et al. Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease—The American Academy of Neurology affirms the value of this statement as an educational tool for neurologists. Stroke 2009;40:2276–93.
  18. Mlynash M, Olivot JM, Tong DC, et al. Yield of combined perfusion and diffusion MR imaging in hemispheric TIA. Neurology 2009;72:1127-33.
  19. Hirai T, Korogi Y, Ono K, et al. Prospective evaluation of suspected stenoocclusive disease of the intracranial artery: combined MR angiography and CT angiography compared with digital subtraction angiography. AJNR Am J Neuroradiol 2002;23:93–101.
  20. Sims JR, Rordorf G, Smith EE, et al. Arterial occlusion revealed by CT angiography predicts NIH stroke score and acute outcomes after IV TPA treatment. AJNR Am J Neuroradiol 2005;26:246–51.
  21. Saqqur M, Uchino K, Demchuk AM, et al. Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke 2007;38:948–54.
  22. Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA. Dec 1 1999;282 (21):2003-11.
  23. Ogawa A, Mori E, Minematsu K, et al. Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial (MELT) Japan. Stroke 2007;38:2633–39.
  24. Gobin YP, Starkman S, Duckwiler GR, Grobelny T, Kidwell CS, Jahan R, et al. MERCI 1: a phase 1 study of Mechanical Embolus Removal in Cerebral Ischemia. Stroke. Dec 2004;35 (12):2848-54.
  25. Smith WS, Sung G, Starkman S, Saver JL, Kidwell CS, Gobin YP, et al. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke. Jul 2005;36 (7):1432-8.
  26. Kidwell CS, Jahan R, Gornbein J, et al. A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med 2013;368:914–23.
  27. Broderick JP, Palesch YY, Demchuk AM, et al. Endovascular therapy after intravenous T-PA versus T-PA alone for stroke. N Engl J Med 2013;368:893–903.
  28. Ciccone A, Valvassori L, Nichelatti M, et al., for the SYNTHESIS Expansion Investigators. Endovascular treatment for acute ischemic stroke. N Engl J Med2013;368:904–13.
  29. Hacke W, Furlan AJ, Al-Rawi Y, et al. Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double- blind, placebo-controlled study. Lancet Neurol 2009;8:141– 50.
  30. Davis SM, Donnan GA, Parsons MW, et al. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol2008;7:299–309.
  31. Albers GW, Thijs VN, Wechsler L, et al. Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol 2006;60:508–17.
  32. Lansberg MG, Straka M, Kemp S, et al. MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol 2012;11:860–67.
  33. Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia — the ischaemic penumbra. Stroke 1981; 12: 723–725.
  34. Hossmann KA. Viability thresholds and the penumbra of focal ischemia. Ann Neurol 1994; 36: 557–565.
Back To Top

Kawakyu-O'Connor, D .  Update on Emergency Imaging of Acute Ischemic Stroke.  J Am Osteopath Coll Radiol.  2014;3(4):2-9.

By Daniel Kawakyu-O’Connor, M.D.| June 01, 2015

About the Author

Daniel Kawakyu-O’Connor, M.D.

Daniel Kawakyu-O’Connor, M.D.

Division of Emergency Imaging, University of Rochester Medical Center, Rochester, NY


 

Copyright © The American College of Osteopathic Radiology 2017